Vol. 248 No. 1 MAY 2019

Editorial: Celebrating 100 Years of the TJEM
100 Years of the Tohoku Journal of Experimental Medicine, and the Tohoku Medical Megabank Project in the Japanese New Era, Reiwa Kazuhiro Takahashi and Shigeki Shibahara [PDF]	Vol. 248, No. 1 pp.1-2, 2019
Invited Review for the 100th Anniversary of the TJEM
Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project Naoko Minegishi, Ichiko Nishijima, Takahiro Nobukuni, Hisaaki Kudo, Noriko Ishida, Takahiro Terakawa, Kazuki Kumada, Riu Yamashita, Fumiki Katsuoka, Soichi Ogishima, Kichiya Suzuki, Makoto Sasaki, Mamoru Satoh, Tohoku Medical Megabank Project Study Group and Masayuki Yamamoto [PDF]	Vol. 248, No. 1 pp.45-55, 2019
Commentary
Antiresorptive Agents and Anti-Angiogenesis Drugs in the Development of Osteonecrosis of the Jaw Alessandro Allegra, Vanessa Innao, Nicolina Pulvirenti and Caterina Musolino [PDF]	Vol. 248, No. 1 pp.27-29, 2019
Regular Contribution
Fraxetin Suppresses Proliferation of Non-Small-Cell Lung Cancer Cells via Preventing Activation of Signal Transducer and Activator of Transcription 3 Yong Zhang, Li Wang, Yan Deng, Peizhu Zhao, Wen Deng, Jing Zhang, Jie Luo and Rongqing Li [PDF]	Vol. 248, No. 1 pp.3-12, 2019
Synovial Fat Deposition of the Knee Is Associated with Degenerative Joint Disorder Tomohiro Suzuki and Shigeru Ehara [PDF]	Vol. 248, No. 1 pp.13-17, 2019
Miyagi Medical and Welfare Information Network: A Backup System for Patient Clinical Information after the Great East Japan Earthquake and Tsunami Keisuke Ido, Naoki Nakamura and Masaharu Nakayama [PDF]	Vol. 248, No. 1 pp.19-25, 2019
Improvement of Cardiac Function by Laparoscopic Adrenalectomy in a Patient with Severe Heart Failure Attributable to Primary Aldosteronism Shin Sato, Yoshihide Kawasaki, Akihiro Ito, Ryo Morimoto, Shuichi Shimada, Takuma Sato, Hideaki Izumi, Naoki Kawamorita, Shinichi Yamashita, Koji Mitsuzuka and Yoichi Arai [PDF]	Vol. 248, No. 1 pp.31-36, 2019
Therapeutic Benefits of Ipilimumab among Japanese Patients with Nivolumab-Refractory Advanced Mucosal Melanoma: A Case Series Study Ken Saijo,1 Hiroo Imai, Kota Ouchi, Yoshinari Okada, Yuko Sato, Keigo Komine, Masahiro Takahashi, Shin Takahashi, Hidekazu Shirota, Masanobu Takahashi and Chikashi Ishioka [PDF]	Vol. 248, No. 1 pp.37-43, 2019
Intrahepatic Cholestasis of Pregnancy as a Clinical Manifestation of Sodium-Taurocholate Cotransporting Polypeptide Deficiency Rong Chen, Mei Deng, Yaqub-Muhammad Rauf, Gui-Zhi Lin, Jian-Wu Qiu, Shun-Ye Zhu, Xiao-Min Xiao and Yuan-Zong Song [PDF]	Vol. 248, No. 1 pp.57-61, 2019