Case Report
Acute Glomerulonephritis Superimposed on Focal Segmental Glomerulosclerosis: A Case Report
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HIROSHI TANAKA, SHINOBU WAGA, TOHRU NAKAHATA, NAOHIRO KONDO,1 NORIO ONODERA1 and NOBUHIRO MONMA2
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Department ofe Pdiatrics, Hirosaki University School of Medicine, Hirosaki 036-8562, 1Division of Pediatrics, Iwate Prefectural Kitakami Hospital, Kitakami 024-0063, and 2Division of Pathology, Morioka Red Cross Hospital, Morioka 020-8560
A 9-year-old boy was referred to our hospital because of significant hematuria and proteinuria associated with hypocomplementemia. Although he had had a 3-year history of asymptomatic persistent proteinuria detected by urine screening of school children, he did not visit a physician. Finally, he visited a regional hospital, and hypocomplementemia was noted there. A percutaneous renal biopsy performed hospital day 4 revealed diffuse endocapillary proliferative glomerulonephritis with severe tubulointerstitial changes. Although his hematuria and hypocomplementemia spontaneously subsided within a month, proteinuria remained. A renal biopsy performed 4 months after the first renal biopsy revealed the lesion suggesting advanced focal segmental glomerulosclerosis (FSGS). Despite corticosteroid treatment, his proteinuria persisted, and he developed end stage renal failure. These clinical observation indicated that he had acute glomerulonephritis (AGN) superimposed on non-nephrotic FSGS, and that the episode of AGN might cause exacerbation of the FSGS.
Key words---
acute glomerulonephritis; exacerbation; focal segmental glomerulosclerosis; superimposed nephritis
© 2000 Tohoku University Medical Press
Tohoku J. Exp. Med., 2000, 191, 177-181
Address for reprints: Hiroshi Tanaka, M.D., Department of Pediatrics Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan.
e-mail: hirotana@cc.hirosaki-u.ac.jp
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