Short Report
Effect of Repeated Electroconvulsive
Shock Treatment on a Depression Model, Mouse Forced Swimming
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MINORU SUZUKI
and YUTAKA
MASUDA1
Department of Neuropsychiatry, and
1Psychosomatic Division, Akita University School of
Medicine, Akita 010-8543
Mouse forced swimming is one
of the behavioral depression models and repeated electroconvulsive
shock (ECS) treatment has been used to human depression. In order to
investigate the mechanism of the anti-depressive effect induced by
repeated ECS, we investigated the effect of repeated ECS with the
mouse forced swimming model. The 5 times par-day ECS remarkably
increased the typical anti-depressive behavior climbing 24 hours
after the final treatment. The anti-depressive activity was declined
by a dopamine 1 antagonist SCH-23390 at the doses of 1 and 0.1 mg/kg,
but not by the other dopamine, serotonin and adrenoceptor antagonists
at the dose of 1 mg/kg. The present findings strongly suggest that
the late anti-depressive effect of repeated ECS is mediated by the
dopamine 1 receptor activity. The present findings will also
contribute to the further investigations of the effect of repeat ECS
treatments on human depression.
Key words--- electroconvulsive shock;
repeated treatment; mouse forced swimming; human depression
© 1999 Tohoku University Medical Press
Tohoku J. Exp. Med., 1999,
189, 83-86
Address for reprints: Minoru Suzuki, Department of
Neuropshychiatry, Akita University School of Medicine, Hondo 1-1-1,
Akita 010-8543, Japan.
e-mail: suzukimi@med.akita-u.ac.jp
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