Effect of Rabeprazole (E3810), a Novel Proton Pump Inhibitor, on Intragastric pH in Healthy Volunteers
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MICHIO HONGO, TAKAYUKI KIMPARA,1 SATOSHI MORIYAMA,1 SHUICHI OHARA,1 SHIN-ICHIRO SONE,1 TAKASHI TAMURA,1 SHIGERU ASAKI1 and TAKAYOSHI TOYOTA1
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Department of Comprehensive Medicine and 1The Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai 980-8574
In this study, we examined the effect of rabeprazole (E3810), a novel proton pump inhibitor, on gastric acidity under physiological conditions in healthy volunteers using 24-hour intragastric pH monitoring. Twenty-four-hour intragastric pH monitoring was performed three times to seven subjects randomly assigned in a cross over fashion to one of the following groups; without drug administration (basal), and with 10 mg or 20 mg of rabeprazole for four days. The median pH for 24 hours was 2.15 in the basal study, while the corresponding median pH were 5.05 and 5.90 after treatment with 10 mg and 20 mg of rabeprazole, respectively. Significant differences in the median pH were observed between the basal study and that after administration of the 10 mg and 20 mg doses of rabeprazole. The cumulative percentage of pH readings above the threshold pH 4 value, was 34.1% in the basal study, and 72.6% and 78.3% after treatment with 10 mg and 20 mg doses of rabeprazole, respectively. This result indicates that the efficacy of rabeprazole allows for substantial control of gastric acidity with once-daily dosing, and that both the 10 mg and 20 mg doses result in potent inhibition of gastric acid secretion.
Key words---
proton pump inhibitor; rabeprazole; antisecretory effect; intragastric pH; pH monitoring
© 1998 Tohoku University Medical Press
Tohoku J. Exp. Med., 1998, 186, 43-50
Address for reprints:
Michio Hongo, M.D., Department of Comprehensive Medicine, Tohoku University School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai 980-8574, Japan.
e-mail: m-hongo@mail.cc.tohoku.ac.jp
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