Tohoku J. Exp. Med., 1997, 181 (4)

Short Report

Neuromuscular Blocking Actions of the Aminoglycoside Antibiotics Sisomicin and Micronomicin in the Rabbit

SHU MATSUKAWA1, JAE-HYUN SUH2, YASUHIKO HASHIMOT02, MASATO KAT02, DAIZOH SATOH1, SHUYA SAIT02, KAZUTAKA END02 and TOSHIO SAISHU3

1Division of Intensive Care Medicine, Tohohu University Hospital, 2Department of Anesthesiology, Tohoku University School of Medicine, and 3Division of Operating Theater, Tohoku University Hospital, Sendai 980-77

  • The neuromuscular blocking actions of sisomicin sulfate (SISO), micronomicin sulfate (MCR) and d-tubocurarine (dTc) were studied in 20 rabbits anesthetized with halothane. The i.v. administration of SISO 20-40 mg/kg, MCR 40-80 mg/kg or dTc 0.1-0.3 mg/kg resulted in dose-dependent decreases in twitch tension. The ED50S for SISO, MCR and dTc were 23.5, 58.2 and 0.2 mg/kg, respectively. SISO- and MCR-induced neuromuscular blockade was partially antagonized by neostigmine or by calcium.
    Key words--- sisomicin; micronomicin; d-tubocurarine; neuromuscular transmission

    Tohoku J. Exp. Med., 1997, 181, 471-473
    Address for reprints: Yasuhiko Hashimoto, M.D., Professor and Chairman, Department of Anesthesiology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai 980-77, Japan.

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