Tohoku J. Exp. Med., 1997, 181 (4)

Short Report

An Evaluation of Neuromuscular Reversal with Edrophonium in a Patient with Malathion Intoxication

SHU MATSUKAWA1, YASUHIKO HASHIMOT02, MASATO KAT02, KUNIHIKO HOSHI1, DAIZOH SATOH1, TAKASHI HORINOUCHI1, SHUN SATOH1 and TOSHIO SAISHU3

1Division of Intensive Care Medicine, Tohoku University Hospital, 2Department of Anesthesiology, Tohoku University School of Medicine, and 3Division of Operating Theater, Tohoku University Hospital, Sendai 980-77

  • We evaluated the neuromuscular reversal with edrophonium using peripheral nerve stimulator and recorder in a patient with malathion intoxication. Edrophonium 10 mg i.v. caused an increase in single twitch tension by 76% of the control during the recovery phase from an acute cholinergic crisis 16 days after ingestion of malathion solution. The present study indicated that edrophonium test seems to be a reliable monitoring in evaluating neuromuscular reversal in the patient with acute malathion insecticide poisoning.
    Key words--- malathion intoxication; edrophonium; cholinergic crisis; neuromuscular reversal

    Tohoku J. Exp. Med., 1997, 181, 467-469
    Address for reprints: Yasuhiko Hashimoto, M.D., Professor and Chairman, Department of Anesthesiology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai 980-77, Japan.

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