Abnormal Lipid Metabolism and Renal Disorders
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TAKAO SAITO
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The Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai 980 - 77
Although renal diseases including nephrotic syndrome and chronic renal failure are associated with
hyperlipidemia, significance of abnormal lipid metabolism has been thought to be limited in some inherited
renal diseases. However, recent studies have postulated that glomerulosclerosis is induced by hyperlipidemia
and is in common with atherosclerosis. This involvement is found in the progressive renal disorders, e.g., focal
glomerular sclerosis, diabetic nephropathy and glycogen storage disease. Interaction between macrophages and
mesangial cells may play an important role in such conditions. This evidence is supported by experimental
models with hyperlipidemia. On the other hand, discovery of new hereditary metabolic disorders, such as type
III hyperlipoproteinemia and lipoprotein glomerulopathy, shows that apolipoprotein (apo) E abnormalities are
responsible for the glomerular lesions. Especially, lipoprotein glomerulopathy has specific features different
from those of lipid-induced renal diseases. In this disease, apo E Sendai which results from new substitution
(Arginine 145 -> Proline) may induce intraglomerular lipoprotein thrombi characteristic of lipoprotein
glomerulopathy.
Key words---
hyperlipidemia; focal glomerular sclerosis; diabetic nephropathy; type III hyperlipoproteinemia; lipoprotein
glomerulopathy
Tohoku J. Exp. Med., 1997, 181, 321-337
Address for reprints:
Takao Saito, M.D., The Second Department of Internal Medicine, Tohoku University School of Medicine, 1-1
Seiryomachi, Aoba-ku, Sendai 980-77, Japan.
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